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Marie Sklodowska-Curie Early Stage Researcher, Studies of Class B G-protein Coupled Receptors
40,143.00 - 40,143.00 per year
Fixed term contract
Apr 21, 2017
Fixed term for 36 monthsApplications are invited for an Early Stage Researcher (ESR)/PhD studentship position funded by The Marie Sklodowska-Curie Actions (MSCA) Innovative Training Networks (ITN) programme ?Rationalising Membrane Protein Crystallisation? (RAMP) and based in the Faculty of Biological Sciences, Astbury Centre for Structural Molecular Biology at the University of Leeds.Integral membrane proteins have essential cellular functions, but understanding their mechanism is difficult because they are hard to express and crystallise. This PhD project is one of 12 in this training network. Other PhD students in the RAMP network will work with other membrane proteins, develop advanced methods for crystallisation and modelling of the membrane protein crystallisation process.This project focuses on conformational trapping and functional reconstitution of a class B GPCR target for structural and biophysical analysis. The applicant will study the conformational/signalling actions during receptor activation/inactivation by scanning (Ala, Cys) library mutants to obtain a high resolution functional map of the receptor : ligand : modulator complex in living cells as well as reconstituted receptors. The conformationally trapped receptor and receptor complexes will be used for structural and biophysical analysis and to gain understanding of the molecular mechanism of the GPCR signalling. The project will involve secondments to other network partners with specialised crystallisation and crystallography expertise, such as NatXRay, the Hamburg Centre for Ultrafast Imgaging, and be cosupervised by Dr. Veli-Pekka Jaakola of Novartis.The project will be carried out in the Astbury Centre for Structural Biology, one of the most diverse, multidisciplinary structural biology centres in the world. It encompasses 75 groups in Physics, Chemistry and Biological Sciences. With a recent £17 million investment by the University of Leeds and further investment by the Wellcome Trust and BBSRC in structural molecular biology, the project will have access to world leading state of the art membrane protein production, X-ray crystallography and cryo-EM facilities.Funding notes:Fully funded EU Innovative Training Network (ITN) studentship for the Rational Approaches to Membrane Protein crystallisation (RAMP). The duration of the appointments is 36 months. Salary (living allowance, mobility allowance, and, if applicable: family allowance) is given in accordance with Marie Curie European regulations.Candidates must comply with both EU and the University of Leeds eligibility criteria. Due to the EU rules to promote mobility, you are not eligible for a position in a country where you have lived (worked, studied) for more than 12 months in the last 3 years. You are eligible for this position, unless you have studied or worked in the UK for more than 12 of the last 36 months. For applicants finishing or who have just finished their degree, this typically means that you can be graduating from any university except a UK university. Candidates should have or be expecting a 2.1 or above at undergraduate level in a relevant subject. If English is not your first language you will be required to meet the University of Leeds English language requirements.Full details of the application process, which includes a CV, cover letter and two letters of reference can be found on the RAMP website, The closing date for applications is 10th May 2017. Both your application, and the letters from referees should be emailed to on or before this date.The start date for this post will be October 2017.
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University of Leeds
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